Protein docking

Proteins often assemble into complexes to achieve a specific biological function. Obtaining high resolution atomistic structures of such complexes, however, is challenging. Software that can predict possible protein arrangements using available experimental data as guide can be exploited. The prediction of the structure of a protein assembly is however often difficult, because when interacting two binding partners may change conformation. Further challenges arise from difficulties in properly combining diverse (and possibly inconsistent) analytical data.

We are developing and applying methods to predict the flexible assembly of proteins into complexes. Our protein docking software, JabberDock, is currently among the best for de novo docking of protein in solution and in a membrane.

Representative articles for method development:

Representative articles for applications: