JabberDock

JabberDock tackles the problem of protein-protein docking while accommodating for rearrangements upon binding including side chain reorientations and backbone flexibility. To this end, JabberDock leverages Spatial and Temporal Influence Density (STID) maps, a representation of proteins surface, electrostatics and local dynamics. Proteins represented as STID maps are docked by maximising their surface complementarity using the POWer optimization engine.

DOWNLOAD

JabberDock is freely available for download on our group’s Github repository:

REFERENCE

When using JabberDock in your work, please cite:

Rudden L.P., Degiacomi M.T. (2019), Protein docking using a single representation for protein surface, electrostatics and local dynamics. Journal of Chemical Theory and Computation