Our study, in collaboration with Durham and Oxford Earth Sciences departments, has been published in Nature Communications. Herein we demonstrate how, in early Earth conditions, layered double-hydroxides could have adsorbed amino acids, favouring the formation of peptidic bonds. We propose that successive wetting-drying cycles could have enabled the formation of peptidic chains having a length compatible to that of simple functional proteins.
Erastova, V., Degiacomi, M.T., Fraser, D.G., Greenwell, H.C. (2017). Mineral surface control for origin of prebiotic peptides, Nature Communications.
All datasets related to this work are available here.
Matteo presented his past and current research during the weekly lunchtime seminar of Durham’s department of Chemistry.
In the gif: an interpretative dance representing the assembly of a small heat shock protein complex.
Welcome to Lucas Powell-Rudden, the first PhD student of the group! Lucas has obtained joint honours in Physics and Chemistry from Durham University, and his work with us will focus on the characterization of integrin structure and dynamics by integrative modelling.
After having attended the Physics of Life Town Meeting in London, Matteo flew to Pisa to join a COST action working group retreat discussing the use and development of computational methods in native mass spectrometry. The three days-long event, on the beautiful Tuscan hills, centred on producing two manuscripts reviewing currently available computational resources, identifying their shortcomings, and defining a roadmap for the whole community. We hope this work will contribute facilitating the uptake of native mass spectrometry approaches, and nucleate the community around a set of commonly shared goals.
We present a new method and associated software, DynamXL, that accommodates intrinsic protein dynamics in the modelling of cross-linking data. Our approach substantially reduces error rates, leading to higher confidence in structure assessment and improved protein-protein docking.
M.T. Degiacomi, C. Schmidt, A.J. Baldwin, J.L.P. Benesch, Accommodating Protein Dynamics in the Modeling of Chemical Crosslinks, Structure, 2017
All data produced in this work are available here: doi:10.15128/r27s75dc36z
The PDRA position is in the scope of the EPSRC-funded project entitled Software for Experimentally Driven Macromolecular Modelling, and is funded for two years. The work will revolve around the development and application of novel integrative modelling methodologies for the study of flexible protein monomers and the prediction of their multimeric arrangement. The position is available from 01/11/2017, or as soon as possible thereafter. Full information (and application form) on Durham University vacancies site (job ID: 008549).
Matteo visited Prof. Carla Schmidt in Halle Martin Luther University. There, he gave a presentation about integrative modelling of heat shock proteins guided by cross-linking, SAXS and IM data, and delivered a 6 hour-long Python scientific programming workshop.
He then travelled to Berlin to attend the Biophysical Society conference “Conformational Ensembles from Experimental Data and Computer Simulations“, where he presented a poster.
Matteo moved in, computers are installed, login to the Hamilton supercomputer granted… let the modelling begin!