After having attended the Physics of Life Town Meeting in London, Matteo flew to Pisa to join a COST action working group retreat discussing the use and development of computational methods in native mass spectrometry. The three days-long event, on the beautiful Tuscan hills, centred on producing two manuscripts reviewing currently available computational resources, identifying their shortcomings, and defining a roadmap for the whole community. We hope this work will contribute facilitating the uptake of native mass spectrometry approaches, and nucleate the community around a set of commonly shared goals.