Lunchtime research meeting

image1.gifMatteo presented his past and current research during the weekly lunchtime seminar of Durham’s department of Chemistry.

In the gif: an interpretative dance representing  the assembly of a small heat shock protein complex.

COST action working group retreat

tuscany1After having attended the Physics of Life Town Meeting in London, Matteo flew to Pisa to join a COST action working group retreat discussing the use and development of computational methods in native mass spectrometry. The three days-long event, on the beautiful Tuscan hills, centred on producing two manuscripts reviewing currently available computational resources, identifying their shortcomings, and defining a roadmap for the whole community. We hope this work will contribute facilitating the uptake of native mass spectrometry approaches, and nucleate the community around a set of commonly shared goals.

New publication: accommodating protein dynamics in the modeling of chemical crosslinks

GAWe present a new method and associated software, DynamXL, that accommodates intrinsic protein dynamics in the modelling of cross-linking data. Our approach substantially reduces error rates, leading to higher confidence in structure assessment and improved protein-protein docking.

M.T. Degiacomi, C. Schmidt, A.J. Baldwin, J.L.P. Benesch, Accommodating Protein Dynamics in the Modeling of Chemical Crosslinks, Structure, 2017

All data produced in this work are available here: doi:10.15128/r27s75dc36z

Postdoctoral position available

The PDRA position is in the scope of the EPSRC-funded project entitled Software for Experimentally Driven Macromolecular Modelling, and is funded for two years. The work will revolve around the development and application of novel integrative modelling methodologies for the study of flexible protein monomers and the prediction of their multimeric arrangement. The position is available from 01/11/2017, or as soon as possible thereafter.  Full information (and application form) on Durham University vacancies site (job ID: 008549).

German tour

IMG_3227Matteo visited Prof. Carla Schmidt in Halle Martin Luther University. There, he gave a presentation about integrative modelling of heat shock proteins guided by cross-linking, SAXS and IM data, and delivered a 6 hour-long Python scientific programming workshop.

He then travelled to Berlin to attend the Biophysical Society conference “Conformational Ensembles from Experimental Data and Computer Simulations“, where he presented a poster.