JabberDock, our protein-protein docking algorithm, has been extended to handle integral membrane proteins. We have created a benchmark set featuring 20 diverse dimers, and used it to demonstrate that our method yields an acceptable solution in its top 10 candidates in 75% of cases.
The first application of JabberDock for membrane proteins has been in the scope of a collaboration with the Kukura group at the University of Oxford. Our models of the protein bo3 oxidase have contributed demonstrating that mass photometry, a novel label-free single molecule technique to measure the mass of biomolecules, can interrogate membrane proteins.
Degiacomi research group 